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IntroductionHousehold mental wellbeing plays an important role in children’s cognitive development, yet evidence from developing countries remains limited. This study examines the relationship between household mental…
IntroductionWorkplace loneliness is increasingly recognized as a critical concern in occupational health psychology. However, the sequential mechanisms through which it translates into organizational detachment remain…
IntroductionHospitals increasingly use algorithmic systems to monitor, compare, score, and appraise employees. Although such systems may improve consistency and efficiency, intensive use may constrain medical…
All currently available instruments for measuring test anxiety are subjective surveys that do not assess functional impairment. Using the attentional control theory of anxiety as its theoretical basis, the Performance…
IntroductionDigital platforms are increasingly used in university physical education (PE), but the psychological pathways associated with platform-supported PE remain insufficiently understood. Because individual random…
IntroductionAs organizations reassess remote work policies in the post-pandemic era, questions remain about how flexible work arrangements impact employee well-being, connection, and turnover.MethodsEmploying a…
Academic resilience is a critical factor in understanding the disparities in student achievement, particularly among disadvantaged groups. This study examined the level of academic resilience in science among native and…
IntroductionEthical leadership has been widely examined as an important antecedent of employee attitudes and behaviors, yet less is known about how it contributes to employees’ eudaimonic well-being at work. Drawing on…
IntroductionSocial withdrawal (Hikikomori) has emerged as a significant public health concern among South Korean young adults. This study investigates how Hikikomori tendencies are associated with the interaction between…
The red blood cell distribution width-to-albumin ratio (RAR) is an index reflecting inflammatory and nutritional status. While prior studies reported cross-sectional associations between RAR and cognitive performance…
Alternative splicing is a fundamental mechanism underlying protein diversity. The microtubule-associated protein tau (MAPT) undergoes age-associated alternative splicing of exon 10 to generate 3 R and 4 R isoforms, and…
Emerging neuroimaging evidence shows that pathological tau proteins build up along specific brain networks, suggesting that large-scale network architecture plays a key role in the progression of Alzheimerâs disease…
Early diagnosis of Parkinsonâs disease (PD) is critical, as clinical symptoms typically emerge only after substantial neuronal loss. While α-synuclein (α-Syn) oligomers in blood are promising biomarkers for early…
Previous studies have demonstrated widespread regional abnormalities in blood oxygen level-dependent (BOLD) amplitude of low frequency fluctuation (ALFF) in psychotic disorders. How regional ALFF is related to functional…
Isolated REM sleep behavior disorder is a high-risk prodromal syndrome for Lewy body diseases but highly heterogeneous. Neurophysiologic markers resolving this heterogeneity and predicting phenoconversion remain limited…
Olfactory decline is an early sign of Parkinsonâs disease (PD), often preceding motor symptoms by years to decades. However, because olfactory impairment is also common in healthy and diseased aging, current olfactory…
A recent publication [1] in this journal reported findings from the use of the tracer [11C]K-2 for PET imaging of brain AMPA receptors in patients with major psychiatric disorders. [11C]K-2 functions by a pro-drug-like…
Ants and bees are known to use spatial memories to navigate to fixed locations, such as a nest. Virtual-reality experiments in which Drosophila fruit flies follow fictive odour plumes now show that these insects use…
Thalamic deep brain stimulation (DBS) is an established neuromodulatory treatment option for drug-resistant epilepsy (DRE), but presurgical markers associated with the postoperative response remain incompletely…
Feeding is tightly regulated by hypothalamic circuits that integrate circadian and metabolic cues, yet the neuromodulatory systems coordinating these signals remain incompletely understood. Cholinergic neurons within the…
V2a interneurons are excitatory neurons found throughout the hindbrain and spinal cord, two regions that arise from distinct progenitors during embryonic development. Whether this lineage difference shapes mature gene…
Na+,K+-ATPases establish and maintain the vital electrochemical gradients for Na+ and K+ across animal cell membranes. The protein is a ternary complex composed of α, β and FXYD subunits, of which isoforms that fine-tune…
Intestinal circadian clocks are emerging as important regulators of gastrointestinal physiology and homeostasis. Recent advances suggest that desynchronization of circadian clocks in distinct intestinal cell types could…
Traditional models of brain connectivity primarily focus on pairwise interactions, overlooking collective dynamics among multiple regions. Although many higher-order interaction (HOI) metrics have been proposed, their…
Dysfunctional mitophagy is proposed as a key component of Alzheimerâs disease (AD) pathology, yet direct in vivo evidence and mechanistic insights are still lacking. Here we show that AD model mice expressing a…
The entorhinal–hippocampal circuit plays a central role in episodic memory, yet the contribution of the medial entorhinal cortex (MEC) ultraslow (< 0.01 Hz) oscillation remains poorly understood. Here, we develop a…
Dietary nicotinamide (NAM) is neuroprotective in rodent models of glaucoma. With dietary delivery, additional systemic influences of NAM are possible, prompting us to test for influences on non-neuronal phenotypes…
Hearing loss is a major modifiable risk factor for Alzheimerâs disease (AD), but how auditory deprivation engages specific neural circuits, particularly in a sex-dependent manner, to promote amyloid pathology remains…
Microglia, the brainâs resident immune cells, are increasingly recognized as key regulators of brain physiology and behavior. However, their specific role in affective states remains controversial, with studies…
Low-dimensional manifolds underlie mental and cognitive representations, and characterizing individual differences is critical to neuropsychiatric research. Existing manifold learning methods either distort…
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