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Real-world evidence on outpatient program participation and time to treatment discontinuation (treatment retention) in patients with gambling disorder in Japan remains limited. In this study, we characterized baseline…
Substance use disorders (SUDs) are increasing globally, and social support as well as access to substance-free activities are essential for sustained recovery. Mental health services should therefore be effective…
Background Buprenorphine is an effective treatment for Opioid Use Disorder (OUD), but many patients discontinue this medication within six-months of initiation and racial disparities in access and retention in…
Sleep disturbances are sometimes reported in clinical settings among individuals with opioid use disorder (OUD) receiving methadone maintenance treatment (MMT). Although numerous studies have explored this issue, a…
Methadone is the gold standard treatment for opioid use disorder (OUD). In the U.S., methadone is usually only available through licensed opioid treatment programs (OTPs), but a 2021 federal rule provided an opportunity…
Background Early adolescent psychoactive substance use poses major health and social risks. School-based programs enhancing psychosocial skills are effective for prevention. This study aims to develop, implement, and…
Integrating pre-exposure prophylaxis (PrEP) into facility-based medication for opioid use disorder (MOUD) and community-based needle and syringe exchange (NSP) programs may optimize service provision and reduce HIV…
Background Methadone is a highly effective treatment for opioid use disorder (OUD). Yet its impact is constrained by low rates of treatment initiation and retention, driven in part by geographic inequalities in the…
Increases in prescribing of buprenorphine for pain or opioid use disorder (OUD) have led to concerns regarding its interactions with other drugs used concomitantly and risk of adverse clinical outcomes. To synthesize…
Substance use disorder (SUD) is prevalent among hospitalized patients, yet most acute care settings do not routinely provide evidence-based SUD treatment. Hospital-based addiction consultation services (ACSs) have…
Empirical evidence supports the use of methadone as the standard of care for opioid use disorder. However, low retention in methadone treatment is one of the largest impediments to treatment success. Although several…
Insomnia and depression frequently co-occur during adolescence, posing significant challenges to adolescent mental health. However, the direction of their association remains inconsistent in the literature and may show…
Elijah Bieniemy, who is charged with shooting his mother, “does not appear able to assist in his own defense," his attorney said.
A first-of-its-kind U.S. study suggests invasive mold infections may be an underappreciated—and potentially deadly—threat.
Nine out of 12 former soldiers saw their symptoms improve after treatment with psilocybin, the main ingredient in magic mushrooms.
Psychology says people who can't stop smiling when they are in front of the camera aren't necessarily pretending to be happy. Smiling during photographs can be linked to social habits, positive ...
The psychological effect of a herpes diagnosis can be greater than the physical symptoms, experts say.
Military veterans with PTSD and other mental health conditions may soon be able to use psychedelic drugs to aid in their treatment. In April, President Trump signed an executive order ...
Many women who've been through difficult chapters don't define themselves by what happened to them. Instead, they develop remarkable strength, empathy and determination. Their words may sometimes ...
Research shows female friendships can support mental health, reduce stress, and improve well-being through emotional connection and social support.
On April 1, the recently renamed Santé Québec Centre-Sud-de-l’Île-de-Montréal – Universitaire, the agency that manages addiction treatment across the island, repatriated responsibility for ...
Children can't say, "I'm longing for connection right now." What they can do is follow you from room to room, melt down at bedtime, or refuse to share. Here's what it means.
A pilot programme designed to equip graduates with practical artificial intelligence skills has been launched by the Tech Industry Alliance and the RDI Hub, bringing together graduates, employers and ...
Proceedings of the National Academy of Sciences, Volume 123, Issue 31, August 2026. SignificanceCellular function depends on stability under fluctuating conditions that occur across diverse timescales. Biomolecular…
Proceedings of the National Academy of Sciences, Volume 123, Issue 31, August 2026. SignificanceHumans adapt by learning from others, but risk acquiring maladaptive behaviors when learning from individuals facing…
Proceedings of the National Academy of Sciences, Volume 123, Issue 31, August 2026. SignificanceOocytes remain quiescent for decades to preserve reproductive capacity, relying on the sustained expression of key proteins…
Proceedings of the National Academy of Sciences, Volume 123, Issue 31, August 2026. SignificanceAutism spectrum disorder (ASD) is strongly linked to synaptic dysfunction, yet the contribution of presynaptic processes to…
Proceedings of the National Academy of Sciences, Volume 123, Issue 31, August 2026. SignificanceLiving organisms possess enzymes that hydrolyze inosine triphosphate (ITP). In humans, inosine triphosphatase (ITPA)…
Proceedings of the National Academy of Sciences, Volume 123, Issue 31, August 2026. SignificanceUbiquitination is a key posttranslational modification in eukaryotes that plays a critical role in diverse cellular…
Proceedings of the National Academy of Sciences, Volume 123, Issue 31, August 2026. SignificanceDespite the global success of folic acid (FA) supplementation in preventing neural tube defects (NTDs), the medical…
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