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Variants in GBA1, encoding lysosomal glucocerebrosidase (GCase), are risk factors for Parkinsonâs disease (PD), which is characterized by α-synuclein (αSyn) accumulation and lysosomal dysfunction. Nonetheless, the…
Neuro-imaging data is necessary for timely and correct diagnosis of the disease Alzheimer’s (AD). Early clinical intervention is challenging due to the high-dimensional nature of the images, making it computationally…
Alzheimer’s disease (AD) is a chronic, multifactorial neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Pathological hallmarks include extracellular amyloid-β (Aβ) deposition and…
Upper limb impairment is one of the most common motor consequences after stroke, and valid assessment tools are essential for evaluating motor capacity. The Wolf Motor Function Test (WMFT) is widely used to measure upper…
Standing up from sitting is a common yet mechanically demanding activity of daily living. Those with motor impairments often have difficulties performing sit-to-stand transfers independently. Robotic devices can help…
Women experience addiction differently than men, with the nature and magnitude of these differences dependent on the clinical phenotype (e.g., progression to addiction vs. relapse vulnerability) and context (e.g., phase…
HIV-Tat and morphine synergistically exacerbate neuroinflammation and DNA damage, yet the mechanisms linking the DNA damage response (DDR), chromatin remodeling, and innate immune activation remain poorly understood…
Astrocytes are increasingly recognised as essential contributors to both physiological brain function and neurodegenerative diseases. Here, we describe how the Parkinsonâs disease (PD)-associated mutation LRRK2-G2019S…
Cerebrospinal fluid (CSF) is thought to facilitate brain waste clearance and immune surveillance, yet its compartmentalization remains unclear. Previous work, using invasive dynamic intrathecal MRI contrast imaging…
Neural manifolds refer to the low-dimensional shapes formed by populations of spiking neurons. This intrinsic population geometry can be physically emulated by electronic devices, facilitating near-training-free…
The astringency surface sub-quality is pivotal to red wine perception, yet its neural bases remain unclear. The approaches of non-invasive neurophysiological techniques, sensory analysis, liquid chromatography-mass…
To examine whether serial casting promotes autonomic nervous system adaptation in children with spastic CP, in comparison to ankle-foot orthoses (AFOs) and no intervention. Thirty children with spastic CP (aged 6–12…
Neuronal polarization is essential for functional compartmentalization, enabling dendritic synaptic integration and axonal action potential generation. Although structural differences in mitochondria across compartments…
Reshaping cortical circuits through stimulation represents an emerging therapy for the restoration of cognitive function1â5, yet the biological mechanisms that underlie its effects remain largely unexplored in humans…
G-protein-coupled receptor-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. Although experiments in transfected cells often reveal selectivity for individual…
Spontaneous biological oscillations are typically attributed to specific architectures within metabolic or gene regulatory networks. Here, we uncover a more general mechanism arising from the interplay between cellular…
Psychological stress is a major precipitating factor for neuropsychiatric disorders, and the gut-brain axis has emerged as a critical regulator of mood and behavior, but how specific commensal microbes modulate host…
Understanding how adverse life events trigger stress-related behavioural changes remains an unresolved challenge. The amygdala is integral to emotion and stress responses1 and comprises astrocytes, neurons and other…
Brains extract relations between objects and concepts and integrate them into cognitive maps for decision-making. But it remains unclear how they achieve that. Here we present a rigorous theory showing that single…
Fear extinction and its persistence depend on epigenetic modifications, which can be potentiated by histone deacetylase inhibitors (HDACis). Butyrate (NaBu), a short-chain fatty acid and endogenous HDACi, promotes…
The spread of dis/misinformation represents a pressing challenge for contemporary society. Addressing this phenomenon requires digital tools as well as an understanding of the mechanisms that enable it. Among the…
Adolescence represents a developmental phase marked by profound and rapidly shifting emotional states. While some adolescents exhibit pronounced, day-to-day mood variability, others remain comparatively stable. Although…
Human social interaction emerges through coordinated behavior, emotion, and physiology. Biobehavioral synchrony supports stress regulation, attachment, and socio-emotional development, yet its manifestation in…
A recent study investigated the relationship between childhood trauma and attention to emotions as a function of type and severity of maltreatment in a sample of women. It was found that high levels of physical and…
In the past, cognitive illusions, such as the repetition-based illusory truth and certainty effects, were primarily studied in experimental settings that were far removed from real-world conditions. However, information…
Understanding when and why social interaction improves human judgment is a central question in the behavioural sciences. We examine whether collective accuracy improves when groups break complex estimation problems into…
Generative artificial intelligence (GenAI) poses new challenges to academic integrity by enabling students to produce plausible academic work with limited detectable overlap. Using a two-wave prospective panel design…
Transcranial focused ultrasound stimulation (tFUS) is an emerging non-invasive neuromodulation technique with unique advantages in targeting deep brain structures with high precision. In this study, we investigated the…
Traditional methods of pattern evidence evaluation in forensic science have long relied on subjective expert judgment, raising concerns about transparency, validity, and reliability. In response, the international…
Insomnia frequently co-occurs with depressive and anxiety symptoms. We examined its prevalence and sociodemographic, lifestyle, health, depressive, and anxiety correlates among adults in Zhuhai, China. Data were from…
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