ResearchJul 20, 2026
One step forward, two steps back: A first look at the planetary health implications of the 2025–2030 Dietary Guidelines for Americans
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026.
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ResearchJul 20, 2026
Shifting cultivation as a self-organizing social–ecological system
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026.
ResearchJul 20, 2026
The dual face of miR-146a in ALS
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026.
ResearchJul 20, 2026
The 2026 western US snow drought was about four times more likely due to climate change
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. In the spring of 2026, anomalously low snow conditions in the western United States threatened winter recreation and water supplies. Here…
ResearchJul 20, 2026
Public responses to atrocities depend on partisanship and context, not legal labels
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. Legal labels such as genocide and crimes against humanity carry substantial legal and diplomatic weight in elite and institutional arenas…
ResearchJul 20, 2026
Record-low 2025 and 2026 ice extents restore Arctic winter sea-ice decline
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. Recent analyses have suggested that the decadal rate of Arctic winter sea-ice extent decline weakened in the early 2020s, with 20-y trends…
ResearchJul 20, 2026
At the boundary: Law and AI
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026.
ResearchJul 20, 2026
Continuity and change in US legal tradition: Evidence from judicial citation communities
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceUsing 760,000 U.S. federal court opinions linked by 8.3 million citations, we identify legal traditions as citation…
ResearchJul 20, 2026
Shape instabilities of active epithelial domes under hydraulic stress: Growth, collapse, and oscillation
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceHow epithelial tissues control the shape dynamics of fluid-filled epithelial cavities remains poorly understood. Using MDCK…
ResearchJul 20, 2026
α-fluoro-β-alanine functions as a β-arrestin1-biased ligand of S1PR2 to upregulate DPD expression in cancer cells
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceHerein, we identify α-fluoro-β-alanine (FBAL), a metabolite of 5-fluorouracil (5-FU), as a β-arrestin1-biased ligand of…
ResearchJul 20, 2026
The backfiring effect of weak AI safety regulation
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceProposed regulatory approaches to promote safe development of AI differentiate between entities developing base models and…
ResearchJul 20, 2026
Glucocorticoid receptors in oligodendrocyte precursor cells regulate hippocampal network plasticity and stress-induced behavior in mice
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceGlucocorticoids shape postnatal brain development and adaptive plasticity through glucocorticoid receptors (GRs), yet their…
ResearchJul 20, 2026
The unique Efg1 fungal virulence regulon in the catheterized bladder environment
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceCatheter-associated urinary tract infections (CAUTIs) are common hospital-acquired infections that can lead to severe…
ResearchJul 20, 2026
Guanidine fuels rapid resurrection of desert cyanobacteria
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceGuanidine is widely distributed in nature and has long been considered a toxic metabolic byproduct. Recent studies have…
ResearchJul 20, 2026
Ligand regulation and function of preformed EGFR dimers
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceThe epidermal growth factor receptor (EGFR) is generally considered to be activated by ligand-induced dimerization…
ResearchJul 20, 2026
Electrochemical lateral flow assay with ELISA-level performance for detecting plant diseases in East Africa
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceRapid diagnostic tests are essential for monitoring health, agriculture, and the environment, yet most lateral flow assays…
ResearchJul 20, 2026
A transition toward flightlessness in Mallards, Indian Runner Ducks, and their hybrid offspring
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceMost birds are specialized for flight. Yet flight is often reduced or lost, and how this occurs is unknown because most losses…
ResearchJul 20, 2026
Quantitative guiding of developmental cell fate patterns using a dynamical landscape model
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceDuring development, cells collectively change their states to generate tissues and organs. In the 1940s, Conrad Waddington…
ResearchJul 20, 2026
Identification of a conserved gene family with an essential role in Leishmania parasite–insect vector adhesion
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceLeishmania, the causative agent of leishmaniasis, has multiple developmental forms as it alternates between a mammalian host…
ResearchJul 20, 2026
Active linking through narratives facilitates associative inference
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceMemory representations are influenced by strategies when information is encoded. Scaffolding information within a narrative is…
ResearchJul 20, 2026
Posttranslational generation of carboxylate ligands from aliphatic side chains in the photosynthetic oxygen-evolving complex
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceOxygen evolution by photosystem II sustains aerobic life and transformed Earth’s early environment by generating the oxygenic…
ResearchJul 20, 2026
A dual self-regulatory platform for programmable biosynthesis of L-lysine-derived alkaloids
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceMany valuable alkaloids used as pharmaceuticals and chemical intermediates are derived from amino acids but are still mainly…
ResearchJul 20, 2026
When children shape their families: Evocative effects analysis of 40,000 trios from the Norwegian Mother, Father and Child Cohort Study
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceFamily research has long emphasized how parents shape their children, but children may also influence their parents. Using…
ResearchJul 20, 2026
Magnetotaxis in an anaerobic ciliate via tripartite syntrophy
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceMagnetotactic bacteria (MTB) swim along Earth’s magnetic field lines via genetically controlled biomineralization of…
ResearchJul 20, 2026
Particles of echovirus 18 open to release their genomes in vivo
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceEnteroviruses are important human pathogens; however, the mechanism by which their genome is released, a prerequisite for…
ResearchJul 20, 2026
Synergistic action of different molecular mechanisms causes striking levels of insecticide resistance in the malaria vector Anopheles gambiae
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceManaging the increasing problem of insecticide resistance in malaria vectors requires a detailed understanding of its genetic…
ResearchJul 20, 2026
Continuity in geometric intuition between humans and monkeys
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceThe unique geometric understanding of humans has been attributed to an evolutionary divide in symbolic cognition that…
ResearchJul 20, 2026
Gender pay gaps in the social sciences
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceThe gender pay gap remains a persistent feature of labor markets, yet its sources are difficult to disentangle. Using detailed…
ResearchJul 20, 2026
Echolocating bats sacrifice binaural localization cues for target-focused hearing during high-speed foraging
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceBats hunt in complete darkness using echolocation, emitting directional high-frequency sonar pulses and analyzing returning…
ResearchJul 20, 2026
Severe floods increase long-term opioid overdose mortality
Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. SignificanceOur study demonstrated a causal link between severe floods and opioid overdose mortality in rural Appalachia, a region that…