Proceedings of the National Academy of Sciences, Volume 123, Issue 33, August 2026. SignificanceWhy DNA uses thymine instead of uracil remains photochemically unresolved, since thymine is more susceptible to ultraviolet…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026.
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceFaithful repair of DNA double-strand breaks (DSBs) during mitosis is critical for genome stability, yet the underlying…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceThe bladder is innervated by complex sensory networks, yet the specific role of stretch-insensitive mucosal nerves has…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceVoltage-gated calcium channels regulate critical physiological processes, and some genetic variants inCACNA1Dcan cause…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceStudies have demonstrated that adoptive cell transfer with antitumor CD4+T cells can be effective in treating advanced stage…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceSevere hand, foot, and mouth disease caused by Enterovirus 71 (EV-A71) threatens global pediatric health, yet its infection…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceAn HIV-1 cure strategy will require novel therapeutics to facilitate immune-mediated elimination of infected cells and…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceIt remains unclear whether developmental transcription factors sustain adult cochlear function. We show that SIX1, known for…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceAnimals respond to injury, infection, or toxic materials via a process called inflammation. At the molecular level…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceOsteoarthritis (OA) is a major cause of pain and disability, yet no approved disease-modifying therapy can halt its…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceThe treatment of hepatocellular carcinoma (HCC) remains challenging, highlighting an urgent need for novel therapeutic…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceMetal oxide transistors are important building blocks for large-area, high-resolution displays due to their high carrier…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceOral cavity squamous cell carcinoma (OCSCC) is a deadly form of head and neck cancer that disproportionately afflicts…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceManaging a pandemic requires balancing competing costs: interventions such as mask mandates and lockdowns reduce infections…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceEvolutionary dynamics selects more fit phenotypes over others. But fitness landscapes are complex and high dimensional, with…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceThe Hawaiian honeycreeper clade is a pre-eminent example of both adaptive radiation and human-mediated rapid extinction. We…
Proceedings of the National Academy of Sciences, Volume 123, Issue 32, August 2026. SignificanceAlthough human brain aging is not uniform across cortical regions, most imaging-derived measures of brain age quantify this…