Current reporting, research and professional developments across Neuropsychology, curated for psychologists and behavioral-health professionals.
Alternative splicing is a fundamental mechanism underlying protein diversity. The microtubule-associated protein tau (MAPT) undergoes age-associated alternative splicing of exon 10 to generate 3 R and 4 R isoforms, and…
Emerging neuroimaging evidence shows that pathological tau proteins build up along specific brain networks, suggesting that large-scale network architecture plays a key role in the progression of Alzheimerâs disease…
Early diagnosis of Parkinsonâs disease (PD) is critical, as clinical symptoms typically emerge only after substantial neuronal loss. While α-synuclein (α-Syn) oligomers in blood are promising biomarkers for early…
Previous studies have demonstrated widespread regional abnormalities in blood oxygen level-dependent (BOLD) amplitude of low frequency fluctuation (ALFF) in psychotic disorders. How regional ALFF is related to functional…
Isolated REM sleep behavior disorder is a high-risk prodromal syndrome for Lewy body diseases but highly heterogeneous. Neurophysiologic markers resolving this heterogeneity and predicting phenoconversion remain limited…
Olfactory decline is an early sign of Parkinsonâs disease (PD), often preceding motor symptoms by years to decades. However, because olfactory impairment is also common in healthy and diseased aging, current olfactory…
A recent publication [1] in this journal reported findings from the use of the tracer [11C]K-2 for PET imaging of brain AMPA receptors in patients with major psychiatric disorders. [11C]K-2 functions by a pro-drug-like…
Ants and bees are known to use spatial memories to navigate to fixed locations, such as a nest. Virtual-reality experiments in which Drosophila fruit flies follow fictive odour plumes now show that these insects use…
Thalamic deep brain stimulation (DBS) is an established neuromodulatory treatment option for drug-resistant epilepsy (DRE), but presurgical markers associated with the postoperative response remain incompletely…
Feeding is tightly regulated by hypothalamic circuits that integrate circadian and metabolic cues, yet the neuromodulatory systems coordinating these signals remain incompletely understood. Cholinergic neurons within the…
V2a interneurons are excitatory neurons found throughout the hindbrain and spinal cord, two regions that arise from distinct progenitors during embryonic development. Whether this lineage difference shapes mature gene…
Na+,K+-ATPases establish and maintain the vital electrochemical gradients for Na+ and K+ across animal cell membranes. The protein is a ternary complex composed of α, β and FXYD subunits, of which isoforms that fine-tune…
Intestinal circadian clocks are emerging as important regulators of gastrointestinal physiology and homeostasis. Recent advances suggest that desynchronization of circadian clocks in distinct intestinal cell types could…
Traditional models of brain connectivity primarily focus on pairwise interactions, overlooking collective dynamics among multiple regions. Although many higher-order interaction (HOI) metrics have been proposed, their…
Dysfunctional mitophagy is proposed as a key component of Alzheimerâs disease (AD) pathology, yet direct in vivo evidence and mechanistic insights are still lacking. Here we show that AD model mice expressing a…
The entorhinal–hippocampal circuit plays a central role in episodic memory, yet the contribution of the medial entorhinal cortex (MEC) ultraslow (< 0.01 Hz) oscillation remains poorly understood. Here, we develop a…
Dietary nicotinamide (NAM) is neuroprotective in rodent models of glaucoma. With dietary delivery, additional systemic influences of NAM are possible, prompting us to test for influences on non-neuronal phenotypes…
Hearing loss is a major modifiable risk factor for Alzheimerâs disease (AD), but how auditory deprivation engages specific neural circuits, particularly in a sex-dependent manner, to promote amyloid pathology remains…
Microglia, the brainâs resident immune cells, are increasingly recognized as key regulators of brain physiology and behavior. However, their specific role in affective states remains controversial, with studies…
Low-dimensional manifolds underlie mental and cognitive representations, and characterizing individual differences is critical to neuropsychiatric research. Existing manifold learning methods either distort…
Memory formation relies on the reorganization of neural activity patterns during experience that persist in subsequent sleep. How these processes promote learning while preserving established memories remains unclear…
Several modifiable risk factors for dementias have been identified including socio-economic status and environmental exposures â however, how these population-level risks relate to individual risk remains elusive. To…
Altercentric and egocentric biases (AB, EB) refer to the impact of another agentâs/own perspective on the speed with which one can report oneâs own/another visual perspective respectively. These biases are known to…
Insomnia symptoms are common and have been associated with disrupted circadian rhythms, altered eating behaviors, and poorer diet quality. Cognitive Behavioral Therapy for Insomnia (CBTi) is recommended as a first-line…
A study conducted by the University of Barcelona provides new evidence on the role of the glymphatic system, which clears waste from the brain, in neurodegenerative diseases. The study shows that patients with conditions…
Glioblastoma is a malignant brain tumor and is among the most aggressive cancers in humans. Despite multimodal therapy with surgery, radiation and chemotherapy, there is still no cure. A major reason is the tumor's…
Researchers have developed a new artificial intelligence-based method that could significantly improve the detection and classification of brain tumors from MRI scans, achieving higher accuracy than conventional…
Scientists at Virginia Tech's Fralin Biomedical Research Institute at VTC have discovered how an experimental therapy can help brain cells overcome the effects of a disease-causing genetic deletion. Instead of repairing…
Published in the Alzheimer’s & Dementia Journal, the study said that even though India’s ageing population faces a ‘dementia burden’, data on what its risk factors actually are is still quite limited.
Eye contact between infants and adult speakers synchronizes their brainwaves to enable language acquisition.
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