Current reporting, research and professional developments across Neuropsychology, curated for psychologists and behavioral-health professionals.
Leisure-time exercise was associated with lower dementia risk in a large systematic review and meta-analysis. In contrast, occupational physical activity was associated with a higher risk of dementia.
Physical activity performed as part of a job raises the risk of dementia, new research suggests. Strenuous labour may not offer the same brain protection as exercising for leisure and may even raise ...
Traveling electrical waves sweeping across the brain may help determine what we notice, predict what comes next, and construct our internal picture of the world. Researchers now argue that these waves aren't just…
During cancer treatment, the same brain tumor can be treated with the same anticancer drug, but the effect can differ from patient to patient. A Korean research team has developed a chip that recreates a patient's own…
If done correctly, this one exercise move "can use almost every muscle in your body," the neurophysiologist said.
J&J's immunology and neuroscience businesses are emerging as key growth engines, with new drugs helping to offset Stelara's loss of exclusivity.
High blood pressure, diabetes and smoking are three major modifiable risk factors of dementia. New research tracked more than 12,000 participants to quantify how many years of healthy cognitive functi ...
Urban neuromodulation and neurofeedback systems have become increasingly adaptive and closed-loop. However, they still focus primarily on brain signals and often ignore the urban areas where these signals happen. The…
Attention is typically regarded as a modulatory process that amplifies or suppresses existing sensory input. Here we tested whether inward-directed (somatic) attention can instead generate bodily sensations. In a…
Visual deprivation provides a critical model for understanding how sensory experience and developmental constraints shape cortical organization. In blindness, the occipital cortex is recruited for tactile and auditory…
Lipocalin-2 (LCN2) has been implicated in the pathogenesis of sepsis-associated encephalopathy (SAE). Our previous work demonstrated a significant increase in astrocyte-derived LCN2 in the hippocampal region during SAE…
Nucleus accumbens (NAc) deep brain stimulation (DBS) has been increasingly explored as a treatment modality for refractory neuropsychiatric disorders. Uncovering the accumbens network that is engaged by DBS is a critical…
Focused ultrasound (FUS) in combination with micro- or nanobubbles is a promising strategy for transiently and non-invasively opening the blood-brain barrier (BBB) to enable targeted drug delivery to the brain. Here, we…
Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock…
With growing knowledge of the neural circuitry involved in alcohol use disorder (AUD), interest in developing neural-circuit-based therapeutic tools, including transcranial magnetic stimulation (TMS), for people with AUD…
Before hearing onset, inner hair cells in altricial mammals show spontaneous electrical activity crucial for proper auditory pathway development. This activity is finely regulated by descending efferent nerves from the…
To establish a rat model of cerebral ischemiaâreperfusion injury (CIRI) to investigate how chloride intracellular channel protein 1 (CLIC1) exacerbates neuronal damage and to assess the neuroprotective effect of its…
Tauopathies are neurodegenerative disorders characterized by the accumulation of hyperphosphorylated tau, leading to synaptic dysfunction, neuroinflammation, and both cognitive and motor impairments. Doxycycline (Doxy)…
Neuroinflammation is responsible for many neurodegenerative diseases and conditions. In this study, neuroprotective effect of resveratrol was aimed to be investigated in lipopolysaccharide (LPS)-induced neuroinflammatory…
Intraventricular hemorrhage (IVH), the most common, severe neurological complication of preterm birth, causes post-hemorrhagic hydrocephalus (PHH) in up to 30% of cases, which is associated with substantial morbidity…
Sleep deprivation substantially impairs driving performance, underscoring the need for Electroencephalography (EEG)-derived markers associated with driving-performance vulnerability under varying levels of sleepiness. In…
Defensive aggression is an evolutionarily conserved instinct, and its dysregulation represents a common behavioral manifestation in multiple psychiatric disorders. Although glucagon-like peptide-1 receptor agonists…
As genetic and biomarker-based dementia risk assessments become more widely used, the challenge is not only estimating risk, but returning it responsibly. Discussing my motherâs APOE genotype with her showed me how…
In Alzheimer’s disease (AD), the role of Actin-binding LIM protein 1 (ABLIM1), which is highly enriched in the brain endothelium, in blood-brain barrier (BBB) dysfunction remains unclear. Our integrative multi-omics…
Peroxiredoxin 3 (PRDX3) encodes a mitochondrially localized antioxidant enzyme. Biallelic pathogenic variants in PRDX3 cause autosomal recessive spinocerebellar ataxia type 32 (SCAR32), a rare form of spinocerebellar…
γ-aminobutyric acid Type-A (GABAA) αβδ receptors regulate neuronal excitability and contribute to sleep, mood and motor coordination. However, the molecular arrangements of these receptors and the basis of GABA…
Sodium fluoride (NaF) is a ubiquitous environmental pollutant that is widespread and has detrimental impacts on ecosystems and health. Developmentally, fluoride exposure enhances oxidative stress, including neurotoxicity…
Yiqi Huoxue Compound (YQHX), a traditional Chinese medicine formulation, has demonstrated therapeutic potential for ischemic stroke (IS). However, its underlying mechanisms are not fully understood. This study aimed to…
Both the immune system and gut microbiome play important roles in the physiological response to stress, yet their interplay under conditions of long-term continuous stress remains poorly understood due to the lack of…
Tamoxifen is widely used clinically as an anticancer therapy and is also commonly employed in transgenic mouse models to induce Cre-dependent recombination. Although its toxicity has been documented across multiple cell…
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