The circadian clock is present throughout the body, including the intestine, where it regulates daily physiology through rhythmic gene expression. The large intestine (colon) is composed of many functionally distinct…
For more than half a century, glaucoma management has relied on a single number: the value of intraocular pressure (IOP) [1]. However, the value we consider with such confidence is not one we ever directly measure! In…
Retinal degeneration results in irreversible visual impairment. In a neurodegenerative animal model, xanthine oxidoreductase inhibitor application reduced disease severity. The present study examined the effect of a…
Astrocyte-derived protein, S100B exerts neurotrophic and neuroprotective effects at physiological concentrations but may promote neuroinflammation and damage when dysregulated. Given its potential role in the…
Psychedelic drugs, such as lysergic acid diethylamide and psilocybin, have emerged as potentially transformative therapeutics for various neuropsychiatric conditions, including depression, anxiety, post-traumatic stress…
The insular cortex has become an increasingly important focus of neuroscientific research because of its broad involvement in psychological and behavioral processes and its dysfunction in neuropsychiatric, developmental…
Glioma pathophysiology is robustly regulated by interactions with neurons. Key to these interactions is the role of neuroligin-3 (NLGN3), a synaptic adhesion molecule shed in response to neuronal activity that functions…
Comorbid depressive symptoms are highly prevalent in patients with chronic colitis, posing a major clinical challenge because pain and depression often fail to respond to the same treatment. However, the neural…
The initiation and maintenance of pain involves complex neuroimmune interactions, with myeloid cell output finetuning the balance between pronociceptive and antinociceptive signaling. Fatty acid binding protein 5 (FABP5)…
Hearing loss is a major modifiable risk factor for cognitive decline and dementia in older adults. This prospective cohort study evaluated five-year cognitive trajectories in individuals aged ≥ 55 years with bilateral…
At Duke University, Sharon Gerechtâs group wanted to construct an in vitro model to study the iBRB. For reproducibility, they needed a stable and consistent supply of both retinal pericytes (RPCs) and RECs. Protocols…
Aging is the most significant factor affecting an individual’s cognitive function. This study aimed to explore the association between light BioAge, a novel indicator to assess aging, and the risk of cognitive impairment…
A DNA tile consists of four double helices that stack together to form a pore with a diameter of 0.8 nanometers. When modified with cholesterol, they can anchor into membranes and mimic ion channels. Jayant says that…
Numerosity perception enables us to quickly estimate the number of objects in a visual scene, a fundamental skill supporting efficient interaction with the environment. In this study, we tracked how the human brain…
The sociopolitical environment can act as a potent stressor with significant consequences for health and well-being. Of increasing global relevance in this context is soft political repression, including denunciation and…
Evidence shows that non-right-handed children are more likely to present with neurodevelopmental conditions compared to their peers, possibly because of brain lateralization differences. This, in turn, suggests that…
Speech analysis is promising for detecting psychiatric symptoms, yet challenged in neurological disorders because of associated motor and cognitive impairments. Here, we used Huntingtonâs disease (HD), an inherited…
This study investigated the association between soccer training and aggressive behavior, alongside underlying resting-state neural substrates. We recruited 48 professional soccer players and 59 controls. Aggression was…
Peer influence is a central yet contested issue in adolescence, a developmental period marked by heightened social sensitivity. The present study examined how adolescents conform to prosocial and antisocial decisions of…
When people encounter new information that challenges their expectations, their pupils are likely to dilate. This physiological response is a sign that something is happening in the brain to help the person adapt to the…
Feed your brain! Harvard research highlights 5 essential foods that boost memory, focus, and long-term mental sharpness ...
A new study demonstrates that over half of people reporting nonordinary experiences experience positive long-term effects, showing that personal appraisal dictates outcome.
Researchers at Yale School of Medicine have conducted the first comprehensive structural analyses of a class of proteins whose dysfunction is associated with neurodegenerative diseases.
It may seem natural to assume that people experience cognitive decline after age 90, but until recently, researchers had limited evidence about how advanced age affects the brain. This major knowledge gap will need to be…
A new study uses single-cell long-read sequencing to map hidden genetic isoforms in glioblastoma, unlocking novel targets for personalized cancer vaccines.
Cortical neural stem cells branch early into parallel lineages, overturning traditional views on how brain cell types form.
A new study introduces EMF-dVAE, a brain-inspired AI model that reduces video processing time by 65% and uses 15% of visual data while improving accuracy.
Phillips' Alzheimer's journey is raising awareness that the disease can affect more than memory, including appearance and everyday life.
Avoiding three things during middle age could mean enjoying up to 13 extra years without dementia, a study has found.
Zoos offer people the opportunity to experience animals and engage with the natural world. Alongside recreation, they also play important roles in species conservation and scientific research. Education is another core…